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李静

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李静 博士

首都师范大学教授,博士生导师

Jing Li, Ph.D.
Professor, Capital Normal University, Beijing, China

Phone:010-68901692
E-mail: jing_li@ mail.cnu.edu.cn

招生方向:细胞

研究方向:蛋白质修饰与人类疾病


教育经历Education 

2006      耶鲁大学分子、细胞及发育生物学系,博士

             (导师:G. Shirleen Roeder, 美国科学院院士)

             Ph. D., Molecular, Cellular and Developmental Biology, Yale University

2001      耶鲁大学分子、细胞及发育生物学系,硕士

             M. S., Molecular, Cellular and Developmental Biology, Yale University

1999      北京大学det365娱乐官网登录,学士

             B. S., College of Life Sciences, Peking University, China  


荣誉Awards

2020        细胞生物学-首批国家级一流本科课程

2019         细胞生物学-首批北京市优质本科课程

2019         首批北京市高校优秀专业课主讲教师

2019         首都师范大学本科生毕业论文(设计)优秀指导教师

2017         北京市首届高等学校青年教学名师

2017         首都师范大学优秀教师

2017         首都师范大学最受学生喜爱导师,十大影响力师门

2016         北京市教委市属高校“创想杯”多媒体课件制作与微课程应用大奖赛三等奖

2015         教育部全国高校教师网络培训中心主办全国高校微课教学比赛 教学设计奖 作品:《细胞周期》

2015-2018      首都师范大学优秀主讲教师

2012         北京市高等教育教学成果奖一等奖(排名第三)

2011          首都师范大学首届青年教师优秀教学奖

2011          首都师范大学2011届本科生毕业论文(设计)优秀指导教师

2011          第七届北京市青年教师教学基本功比赛二等奖

2010          霍英东教育基金会第十二届高等院校青年教师奖三等奖

2009         首都师范大学青年教师教学基本功竞赛一等奖,最佳教案奖

2007         北京市科技新星

1999-2006      耶鲁大学━香港范氏奖学金 (Fan Fellowship)

1998         北京大学光华奖奖学金


工作经历Professional Experience

2018.1-今             首都师范大学教授

                           Professor, CNU

2019.1-今             首都师范大学生物科学专业负责人

2009.1-2019.12     首都师范大学生科院细胞生物学教学团队队长

                          Director, Cell Biology Teaching Group, CNU

2008.9-2012.12     首都师范大学生科院院长助理

                          Dean Assistant, College of Life Sciences, CNU                

2008.1-2017.12     首都师范大学副教授

                          Associate Professor, CNU

2007.5-2007.12     首都师范大学讲师

                           Assistant Professor, CNU

2006.4-2006.7      耶鲁大学分子、细胞及发育生物学系,博士后

                           Postdoctoral Associate, MCDB, Yale University


教材

1.李静,印莉萍,于荣, 《细胞生物学数字课程》, 高等教育出版社,2019,ISBN:978-7-89510-559-1

2.印莉萍,李静,于荣,《细胞生物学实验技术教程》(第四版),科学出版社,2015, ISBN:978-7-03-044357-1

3.许兴智,佟伟民,李静,杨跃,丛羽生, 《癌症的分子基础》, 科学出版社,2011,978-7-0-303160-7



学术兼职

2022            国家重点研发计划青年科学家项目函评专家

2021-2025    中国生物物理学会糖生物学分会委员会委员

2021             教育部全国优秀教材函评专家,国家级一流本科课程函评专家

2021              国自然优青函评专家

2020             国自然生命科学部交叉融合科学处函评专家

2020             上海嘉会医疗,顾问

2019-2024     苏州生物医药创新中心,学术委员会委员

2019-            教育部学位中心函评专家

2019              国自然生物二处、交叉融合科学处函评专家

2017-           《中国生物化学与分子生物学报》英文编辑


参与审稿的学术期刊

Nature Chemical Biology, Nucleic Acids Research, Frontiers in Pharmacoloy, Journal of Genetics and Genomics, Pharmaceuticals, Frontiers in Oncology, Frontiers in Genetics, Cell Cycle, Scientific Reports, Cancer Medicine, Medical Research Archives, Journal of Cancer Biology & Research,《遗传》,《中国生物化学与分子生物学报》


编辑(Editorial

客座副编辑(Guest Associate Editor):PLOS Genetics (2022), Frontiers in Endocrinology (2022)


研究概述

蛋白质的翻译后修饰(包括磷酸化、泛素化以及O-GlcNAc糖基化)参与有丝分裂后期染色体分离及胞质分离过程以及DNA 损伤检验点的机制研究,及其与人类疾病的关系。

Research Description

Mechanistic studies of protein post translational modifications (PTMs), e.g. phosphorylation, ubiquitination and O-GlcNAc glycosylation, involved in the process of chromosome segregation and cytokinesis during unperturbed cell cycle, as well as in the DNA damage repair network (DDR), with particular emphasis on its relationship with human diseases.


Publications (Corresponding *)
(第一/通讯20 篇,其中Nature Index 5 )

1. Sheng Yan1, Bin Peng1, Shifeng Kan1, Guangcan Shao, Xiangyan Tang, Yong-Xiang Chen, Meng-Qiu Dong, Xiao Liu*, Xingzhi Xu* and Jing Li* 2022 PLK1 O-GlcNAcylation is essential for dividing mammalian cells and inhibits uterine carcinoma. Submitted

2. Ningda Xu1, Yue Liu1, Shanshan Nai1, Yong Tao1, Yuehe Ding, Lemei Jia, Qizhi Geng, Jie Li, Yujing Bai, Gong-Hong Wei, Meng-Qiu Dong, Linyi Luo, Mingwei Zhao, Xingzhi Xu, Xiao-Xin Li*, Jing Li* and Lvzhen Huang* 2022. UBE3D is involved in blue light-induced retinal damage by regulating double-strand break repair. Investigative Ophthalmology & Visual ScienceIOVS accepted (TOP)

3. Yingxin Shi1, Sheng Yan1, Guang-Can Shao1, Jinglong Wang, Yong-Ping Jian, Bo Liu, Yanqiu Yuan, Ke Qin, Shanshan Nai, Xiahe Huang, Yingchun Wang, Zhenghui Chen, Xing Chen, Meng-Qiu Dong, Yiqun Geng*, Zhi-Xiang Xu* and Jing Li* 2022 O-GlcNAcylation stabilizes the autophagy-initiating kinase ULK1 by inhibiting chaperone-mediated autophagy upon HPV infection. Journal of Biological Chemistry. doi: 10.1016/j.jbc.2022.102341. (TOP)

4. Yanfang Chen, Guang-Can Shao, Jie Li, An-Qi Yang, Jing Li and Xinshan Ye* 2022 O-GlcNAcylation of Blimp-1 in Lymphocytes Inhibits Its Transcriptional Function and Is Associated with Migration and Invasion of Breast Cancer Cells. Molecular Cancer Research, 20(4):650-660

5. Jing-Jing Zhu1, Yanfang Chen1, Jing Li, and Xin-Shan Ye*. 2022 O-GlcNAcylation increases PYGL activity by promoting phosphorylation. Glycobiology 32(2):101-109

6. Aiyun Yuan1, Xiangyan Tang1 and Jing Li* 2021 Centrosomes: Til O-GlcNAc do us apart. Frontiers in Endocrinology 11:621888

7. 李静*,谭忠平 2020 葡糖酰胺(O-GlcNAc)修饰:细胞内糖基化的前世今生 《中国生物化学与分子生物学报》 (特约综述)36(9): 987-1001

8. Bo Ma, Xiaoyang Guan, Yaohao Li, Shiying Shang, Jing Li* and Zhongping Tan*. 2020 Protein glycoengineering: An approach for improving protein properties. Frontiers in Chemistry.8:622

9. Caifei Liu1, Yingxin Shi1, Jie Li1, Xuewen Liu, Zhikai Xiahou, Zhongping Tan, Xing Chen and Jing Li*. 2020 O-GlcNAcylation of myosin phosphatase targeting subunit 1 (MYPT1) dictates timely disjunction of centrosomes. Journal of Biological Chemistry. 295(21):7341-7349 (TOP)

10. Fu-Cheng Wang, Bin Peng, Sheng-Li Cao, Hong-Yun Li, Xiao-Li Yuan, Ting-Ting Zhang, Ruifeng Shi, Zhuqing Li, Ji Liao, Hailong Wang, Jing Li and Xingzhi Xu*. 2020 Synthesis and cytotoxic activity of chalcone analogues containing a thieno[2,3-d]pyrimidin-2-yl group as the A-ring or B-ring. Bioorganic Chemistry 10:103346

11. Shanshan Nai1, Yingxin Shi1, Huanwei Ru1, Yuehe Ding, Qizhi Geng, Zhe Li, Meng-Qiu Dong, Xingzhi Xu and Jing Li* 2019 Chk2-dependent phosphorylation of myosin phosphatase targeting subunit 1 (MYPT1) regulates centrosome maturation. Cell Cycle 18(20):2651-2659

12. Xue Han1, Bin Peng1, Bei-Bei Xiao1, S.-Li Cao*, Chao-Rui Yang, Wen-Zhu Wang, Fu-Cheng Wang, Hong-Yun Li, Xiao-Li Yuan, Ruifeng Shi, Ji Liao, Hailong Wang, Jing Li, Xingzhi Xu*. 2019 Synthesis and evaluation of chalcone analogues containing a 4-oxoquinazolin-2-yl group as potential anti-tumor agents. European Journal of Medicinal Chemistry. 162:586-601

13. Caifei Liu and Jing Li* 2018 O-GlcNAc: a sweetheart of the cell cycle and DNA damage response. Frontiers in Endocrinology (Invited) 9:415.[ O-GlcNAcylation: expanding the frontiers (eBook , 2020): ISSN 1664-8714; ISBN 978-2-88963-425-5; DOI 10.3389/978-2-88963-425-5]

14. Xiaomei Hu1, Zhe Li1, Yuehe Ding, Qizhi Geng, Zhikai Xiahou, Huanwei Ru, Meng-Qiu Dong, Xingzhi Xu and Jing Li*. 2018 Chk1 modulates the interaction between myosin phosphatase targeting protein 1 (MYPT1) and protein phosphatase 1cβ (PP1cβ). Cell Cycle. 17 (4): 421–427

15. Chao-rui Yang1, Bin Peng1, Sheng-Li Cao*, Ting-ting Ren, Wei Jiang, Fu-Cheng Wang, You-Shan Li, Guo Wang, Zheng Li, Shibin Xu, Ji Liao, Hailong Wang, Jing Li, Xingzhi Xu*. 2018. Synthesis, cytotoxic evaluation and target identification of thieno[2,3-d]pyrimidine derivatives with a dithiocarbamate side chain at C2 position. European Journal of Medicinal Chemistry, 154: 324-340

16. Xiaolu Ma1, Hongmei Liu1, Jing Li1,Yihao Wang, Yuehe Ding, Hongyan Shen, Yeran Yang, Chenyi Sun,Min Huang, Yingfeng Tu,Yang Liu,Yongliang Zhao, Mengqiu Dong, Ping Xu, Tie-Shan Tang*,  Caixia Guo* 2017 Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis. Nature Communications. 8(1):1941. (1 Equal Contributions) (TOP)

17. Jie Tian1, Yingxing Shi1, Shanshan Nai, Qizhi Geng, Lei-Liang Zhang, Gong-Hong Wei, Xingzhi Xu* and Jing Li*. 2017. Ataxin-10 is involved in Golgi membrane dynamics. Journal of Genetics and Genomics. 44(11):549-552

18. Zhe Li1Xueyan Li1Shanshan Nai, Qizhi Geng, Ji Liao, Xingzhi Xu* and Jing Li*. 2017 Checkpoint kinase 1-induced phosphorylation of O-Linked β-N-Acetylglucosamine transferase regulates the intermediate filament network during cytokinesis. Journal of Biological Chemistry. 292(48) 19548–19555 (TOP)

19. Xueyan Li, Shanshan Nai, Yuehe Ding, Qizhi Geng, Bingtao Zhu, Kai Yu, Wei-Guo Zhu, Meng-Qiu Dong, Xiao-Dong Su, Xingzhi Xu* and Jing Li*. 2017 Polo-like kinase 1 (PLK1)-dependent phosphorylation of methylenetetrahydrofolate reductase (MTHFR) regulates replication via histone methylation. Cell Cycle 16(20):1933-1942

20. Li YS, Peng B, Ma L, Cao SL, Bai LL, Yang CR, Wan CQ, Yan HJ, Ding PP, Li ZF, Liao J, Meng YY, Wang HL, Li J, Xu X. 2017 Synthesis, crystal structures and antitumor activity of two platinum(II) complexes with methyl hydrazinecarbodithioate derivatives of indolin-2-one. Eur J Med Chem. 127:137-146.

21. Jing Li* and Xingzhi Xu*. 2016 DNA double-strand break repair: a tale of pathway choices. Acta Biochimica et Biophysica Sinica. 48(7):641-6.

22. Jie Tian1, Qizhi Geng1, Yuehe Ding, Ji Liao, Meng-Qiu Dong, Xingzhi Xu* and Jing Li*. 2016 O-GlcNAcylation antagonizes phosphorylation of Cdh1 (CDC20 homologue 1). Journal of Biological Chemistry. 291(23):12136-44. (TOP)

23. Ding PP, Gao M, Mao BB, Cao SL, Liu CH, Yang CR, Li ZF, Liao J, Zhao H, Li Z, Li J, Wang H, Xu X. 2016.Synthesis and biological evaluation of quinazolin-4(3H)-one derivatives bearing dithiocarbamate side chain at C2-position as potential antitumor agents. Eur J Med Chem. 108:364-73

24. ­­­­­­Jie Tian, Chuan Tian, Yuehe Ding, Zhe Li, Qizhi Geng, Zhikai Xiahou, Jue Wang, Wenya Hou, Ji Liao, Meng-Qiu Dong, Xingzhi Xu* and Jing Li*. 2015 Aurora B-dependent phosphorylation of Ataxin-10 promotes the interaction between Ataxin-10 and Plk1 in cytokinesis. Scientific Reports. 58360

25. Zhao H, Zhu M, Dou G, Zhao H, Zhu B, Li J, Liao J, Xu X. BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response. 2014  Cell Cycle. 13(11):1777-87.

26. Jing Li1,*, Xiaoqian Liu1, Ji Liao, Jie Tian, Jue Wang, Xin Wang, Jiezhong Zhang and Xingzhi Xu*. 2013. MYPT1 sustains centromeric cohesion and the spindle-assembly checkpoint. Journal of Genetics and Genomics. 40(11):575-8.

27. Jinping Liu, Linli Xu, Jianing Zhong, Ji Liao, Jing Li and Xingzhi Xu. 2012. Protein phosphatase PP4 is involved in NHEJ-mediated repair of DNA double-strand breaks. Cell Cycle 11(14), 2643-49 (Commentary on Cell Cycle 11(14), 2590)

28. Jinping Liu, Shukun Luo, Hongchang Zhao, Ji Liao, Jing Li, Chunying Yang, Bo Xu, David F. Stern, Xingzhi Xu* and Keqiong Ye*. 2012. Structural mechanism of the phosphorylation-dependent dimerization of MDC1 forkhead-associated domain. Nucleic Acids Research 40(9):3898-3912 (featured article)

29. Li J1,*., Wang, J1., Hou, W1., Jing, Z., Tian, C., Han, Y., Liao, J., Dong, M-Q., Xu, X*. 2011. Phosphorylation of Ataxin-10 by polo-like kinase 1 is required for cytokinesis. Cell Cycle 10(17)2946 – 2958 (cover article)

30. Zhong J, Liao J, Liu X, Wang P, Liu J, Hou W, Zhu B, Yao L, Wang J, Li J, Stark JM, Xie Y, Xu X. 2011 Protein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaks. Cell Cycle 10(9):1411-1419

31. Lv, S., Bu, W., Jiao, H., Liu, B., Zhu, L., Zhao, H., Li, J., Liao, J., Xu, X. 2010. LSD1 is required for chromosome segregation during mitosis. Eur. J. Cell Biol. 89(7):557-63

32. Li, J*., Wang, J., Jiao, H., Liao, J., and Xu, X*. 2010. Cytokinesis and cancer: Polo loves ROCK’n’Rho(A). Journal of genetics and genomics 37 (3)159-172

33. Wang, H., Zhao, A., Chen, L., Zhong, X., Liao, J., Gao, M., Cai, M., Lee, D.H., Li, J., Chowdhury, D., Yang, Y.G., Pfeifer, G.P., Yen, Y., and Xu, X. 2009. Human RIF1 encodes an anti-apoptotic factor required for DNA repair. Carcinogenesis 30(8):1314-1319

34. Zhang, X., Liu, D., Lv, S., Wang, H., Zhong, X., Liu, B., Wang, B., Liao, J., Li, J., Pfeifer G. P., and Xu, X. 2009. CDK5RAP2 is required for spindle checkpoint function. Cell Cycle 8(8): 1206-1216.

35. Wang, B., Zhao, A., Sun, L., Zhong, X.. Zhong, J., Wang, H., Cai, M., Li, J., Xu, Y., Liao, J., Sang, J., Chowdhury, D., Pfeifer, G.P., Yen, Y., and Xu, X. 2008. Protein phosphatase PP4 is overexpressed in human breast and lung tumors. Cell Research 18:974-977

36. Li, J., Agarwal, S., and Roeder, G.S. 2007 SSP2 and OSW1, Two sporulation-specific genes involved in spore morphogenesis in Saccharomyces cerevisiae. Genetics. 175(1)143-154

37. Li, J., Hooker, G.W., and Roeder, G.S. 2006. Saccharomyces cerevisiae Mer2, Mei4 and Rec114 form a complex required for meiotic double-strand break formation. Genetics, 173(4): 1969-1981

38. Huafei Lu, Xiaotian Ming, Lijia Qu, Meihua Liu, Jing Li, Hongya Gu, Zhangliang Chen. 2000. Construction of chimeric inducible promoters by elicitors of rice fungal blast pathogen and their expression in transgenic rice. Chinese Science Bulletin, 45(3):242-246